Science

Committed to Regenerative Medicine

Through continuous research and development, we are committed to advancing health through regenerative science.

Publications

Articles and publications which support the scientific rationale and clinical outcomes achieved via our products in regenerative aesthetics and medicine.

General Science

Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002 Dec;13(12):4279-95. PubMed PMID: 12475952; PubMed Central PMCID: PMC138633

Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res. 2007 May 11;100(9):1249-60. Review. PubMed PMID: 17495232; PubMed Central PMCID: PMC5679280

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143-7. PubMed PMID: 10102814

Franz A, Wood W, Martin P. Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection. Dev Cell. 2018 Feb 26;44(4):460-470.e3. doi: 10.1016/j.devcel.2018.01.026. PubMed PMID: 29486196; PubMed Central PMCID: PMC6113741

Eto H, Kato H, Suga H, Aoi N, Doi K, Kuno S, Yoshimura K. The fate of adipocytes after nonvascularized fat grafting: evidence of early death and replacement of adipocytes. Plast Reconstr Surg. 2012 May;129(5):1081-92. doi: 10.1097/PRS.0b013e31824a2b19. PubMed PMID: 22261562

Bora P, Majumdar AS. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation. Stem Cell Res Ther. 2017 Jun 15;8(1):145. doi: 10.1186/s13287-017-0598-y. Review. PubMed PMID: 28619097; PubMed Central PMCID: PMC5472998

Burrow KL, Hoyland JA, Richardson SM. Human Adipose-Derived Stem Cells Exhibit Enhanced Proliferative Capacity and Retain Multipotency Longer than Donor-Matched Bone Marrow Mesenchymal Stem Cells during Expansion In Vitro. Stem Cells Int. 2017;2017:2541275. doi: 10.1155/2017/2541275. Epub 2017 May 3. PubMed PMID: 28553357; PubMed Central PMCID: PMC5434475

Shen JF, Sugawara A, Yamashita J, Ogura H, Sato S. Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues. Int J Oral Sci. 2011 Jul;3(3):117-24. doi: 10.4248/IJOS11044. Review. PubMed PMID: 21789960; PubMed Central PMCID: PMC3470092

Dodson MV, Hausman GJ, Guan L, Du M, Jiang Z. Potential impact of mature adipocyte dedifferentiation in terms of cell numbers. Int J Stem Cells. 2011 Jun;4(1):76-8. PubMed PMID: 24298337; PubMed Central PMCID: PMC3840976

Cawthorn WP, Scheller EL, MacDougald OA. Adipose tissue stem cells meet preadipocyte commitment: going back to the future. J Lipid Res. 2012 Feb;53(2):227-46. doi: 10.1194/jlr.R021089. Epub 2011 Dec 2. Review. PubMed PMID: 22140268; PubMed Central PMCID: PMC3269153

El-Badawy A, Amer M, Abdelbaset R, Sherif SN, Abo-Elela M, Ghallab YH, Abdelhamid H, Ismail Y, El-Badri N. Adipose Stem Cells Display Higher Regenerative Capacities and More Adaptable Electro-Kinetic Properties Compared to Bone Marrow-Derived Mesenchymal Stromal Cells. Sci Rep. 2016 Nov 24;6:37801. doi: 10.1038/srep37801. PubMed PMID: 27883074; PubMed Central PMCID: PMC5121630

Condé-Green A, Kotamarti VS, Sherman LS, Keith JD, Lee ES, Granick MS, Rameshwar P. Shift toward Mechanical Isolation of Adipose-derived Stromal Vascular Fraction: Review of Upcoming Techniques. Plast Reconstr Surg Glob Open. 2016 Sep 7;4(9):e1017. eCollection 2016 Sep. PubMed PMID: 27757339; PubMed Central PMCID: PMC5055005

Liao Y, Zeng Z, Lu F, Dong Z, Chang Q, Gao J. In vivo dedifferentiation of adult adipose cells. PLoS One. 2015 Apr 22;10(4):e0125254. doi: 10.1371/journal.pone.0125254. eCollection 2015. PubMed PMID: 25901360; PubMed Central PMCID: PMC4406742

Aesthetics

Yoshimura K, Suga H, Eto H. Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regen Med. 2009 Mar;4(2):265-73. doi: 10.2217/17460751.4.2.265. Review. PubMed PMID: 19317645

Gause TM 2nd, Kling RE, Sivak WN, Marra KG, Rubin JP, Kokai LE. Particle size in fat graft retention: A review on the impact of harvesting technique in lipofilling surgical outcomes. Adipocyte. 2014 Dec 10;3(4):273-9. doi: 10.4161/21623945.2014.957987. eCollection 2014 Oct-Dec. Review. PubMed PMID: 26317051; PubMed Central PMCID: PMC4550681

Gir P, Oni G, Brown SA, Mojallal A, Rohrich RJ. Human adipose stem cells: current clinical applications. Plast Reconstr Surg. 2012 Jun;129(6):1277-90. doi: 10.1097/PRS.0b013e31824ecae6. Review. PubMed PMID: 22634645

Banyard DA, Salibian AA, Widgerow AD, Evans GR. Implications for human adipose-derived stem cells in plastic surgery. J Cell Mol Med. 2015 Jan;19(1):21-30. doi: 10.1111/jcmm.12425. Epub 2014 Nov 26. Review. PubMed PMID: 25425096; PubMed Central PMCID: PMC4288346

Cohen SR, Hewett S, Ross L, Fischer M, Saad A, Teubel S, Delaunay F. Progressive Improvement in Midfacial Volume 18-24 Months After Simultaneous Fat Grafting and Facelift: An Insight to Fat Graft Remodeling. Aesthet Surg J. 2018 Oct 18. doi: 10.1093/asj/sjy279. [Epub ahead of print] PubMed PMID: 30335128

Philips BJ, Marra KG, Rubin JP. Healing of grafted adipose tissue: current clinical applications of adipose-derived stem cells for breast and face reconstruction. Wound Repair Regen. 2014 May;22 Suppl 1:11-3. doi: 10.1111/wrr.12164. Review. PubMed PMID: 24813358; PubMed Central PMCID: PMC4756904

Cohen SR, Hewett S, Ross L, Delaunay F, Goodacre A, Ramos C, Leong T, Saad A. Regenerative Cells For Facial Surgery: Biofilling and Biocontouring. Aesthet Surg J. 2017 Jul 1;37(suppl_3):S16-S32. doi: 10.1093/asj/sjx078. Review. PubMed PMID: 29025218

Kokai LE, Marra K, Rubin JP. Adipose stem cells: biology and clinical applications for tissue repair and regeneration. Transl Res. 2014 Apr;163(4):399-408. doi: 10.1016/j.trsl.2013.11.009. Epub 2013 Dec 4. Review. PubMed PMID: 24361334

Turer DM, Rubin JP. Commentary on: Safe Gluteal Fat Graft Avoiding a Vascular or Nervous Injury: An Anatomical Study in Cadavers. Aesthet Surg J. 2019 Jan 17;39(2):185-186. doi: 10.1093/asj/sjy302. PubMed PMID: 30657925

Lindegren A, Schultz I, Wickman M. Improved patient-reported outcomes after autologous fat transplantation and corrective surgery after breast surgery. J Plast Surg Hand Surg. 2019 Jan 17:1-8. doi: 10.1080/2000656X.2018.1561456. [Epub ahead of print] PubMed PMID: 30652957

Wang GH, Zhao JF, Xue HY, Li D. Facial aesthetic fat graft retention rates after filtration, centrifugation, or sedimentation processing techniques measured using three-dimensional surface imaging devices. Chin Med J (Engl). 2019 Jan 5;132(1):69-77. doi: 10.1097/CM9.0000000000000016. PubMed PMID: 30628961

Chia CT, Theodorou SJ, Dayan E, Tabbal G, Del Vecchio D. “Brazilian Butt Lift” under Local Anesthesia: A Novel Technique Addressing Safety Concerns. Plast Reconstr Surg. 2018 Dec;142(6):1468-1475. doi: 10.1097/PRS.0000000000005067. PubMed PMID: 30489520

Orthopedics

Pers YM, Jorgensen C. Adipose derived stem cells for regenerative therapy in osteoarticular diseases. Horm Mol Biol Clin Investig. 2016 Dec 1;28(3):113-120. doi: 10.1515/hmbci-2016-0010. Review. PubMed PMID: 27092656

Roato I, Belisario DC, Compagno M, Lena A, Bistolfi A, Maccari L, Mussano F, Genova T, Godio L, Perale G, Formica M, Cambieri I, Castagnoli C, Robba T, Felli L, Ferracini R. Concentrated adipose tissue infusion for the treatment of knee osteoarthritis: clinical and histological observations. Int Orthop. 2019 Jan;43(1):15-23. doi: 10.1007/s00264-018-4192-4. Epub 2018 Oct 11. PubMed PMID: 30311059

Coughlin RP, Oldweiler A, Mickelson DT, Moorman CT 3rd. Adipose-Derived Stem Cell Transplant Technique for Degenerative Joint Disease. Arthrosc Tech. 2017 Oct 2;6(5):e1761-e1766. doi: 10.1016/j.eats.2017.06.048. eCollection 2017 Oct. PubMed PMID: 29399463; PubMed Central PMCID: PMC5795060

Hudetz D, Borić I, Rod E, Jeleč Ž, Radić A, Vrdoljak T, Skelin A, Lauc G, Trbojević-Akmačić I, Plečko M, Polašek O, Primorac D. The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis. Genes (Basel). 2017 Oct 13;8(10). pii: E270. doi: 10.3390/genes8100270. PubMed PMID: 29027984; PubMed Central PMCID: PMC5664120

Bansal H, Comella K, Leon J, Verma P, Agrawal D, Koka P, Ichim T. Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis. J Transl Med. 2017 Jun 19;15(1):141. doi: 10.1186/s12967-017-1242-4. PubMed PMID: 28629466; PubMed Central PMCID: PMC5477422

Fellows CR, Matta C, Zakany R, Khan IM, Mobasheri A. Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair. Front Genet. 2016 Dec 20;7:213. doi: 10.3389/fgene.2016.00213. eCollection 2016. Review. PubMed PMID: 28066501; PubMed Central PMCID: PMC5167763

Miscellaneous

Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, Aiba-Kojima E, Sato K, Inoue K, Nagase T, Koshima I, Gonda K. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol. 2006 Jul;208(1):64-76. PubMed PMID: 16557516

Baptista LS, do Amaral RJ, Carias RB, Aniceto M, Claudio-da-Silva C, Borojevic R. An alternative method for the isolation of mesenchymal stromal cells derived from lipoaspirate samples. Cytotherapy. 2009;11(6):706-15. doi: 10.3109/14653240902981144. PubMed PMID: 19878057

Bowen RE. Stromal Vascular Fraction from Lipoaspirate Infranatant: Comparison Between Suction-Assisted Liposuction and Nutational Infrasonic Liposuction. Aesthetic Plast Surg. 2016 Jun;40(3):367-71. doi: 10.1007/s00266-016-0631-z. Epub 2016 Apr 8. PubMed PMID: 27059045

Tedesco M. Adipose tissue transplant in recurrent folliculitis decalvans. Int J Immunopathol Pharmacol. 2018 Mar-Dec;32:2058738418814688. doi: 10.1177/2058738418814688. PubMed PMID: 30482066; PubMed Central PMCID: PMC6259063

Anderi R, Makdissy N, Azar A, Rizk F, Hamade A. Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata. Stem Cell Res Ther. 2018 May 15;9(1):141. doi: 10.1186/s13287-018-0889-y. PubMed PMID: 29764513; PubMed Central PMCID: PMC5952577